Hemoglobin Variants and Hemoglobin A1c Analysis: Problem Solved?
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منابع مشابه
Hemoglobin variants and hemoglobin A1c analysis: problem solved?
Measurement of glycohemoglobin (GHb) is an integral component of the management of patients with diabetes mellitus (1, 2). Glycation is the nonenzymatic addition of a sugar residue to amino groups of proteins. Numerous proteins in the body are glycated, but GHb in blood is the analyte most widely used clinically to monitor glycemic control. The concentration of GHb is directly proportional to t...
متن کاملHemoglobin A1c: Clinical applications and analytical considerations
Diabetes Mellitus (DM) is the most common disorder of carbohydrate metabolism. Hyperglycemia is the common feature of DM. Hyperglycemia causes cardiovascular, renal, ocular, and peripheral nerve disorders in patients with diabetes. Glycemic regulation plays an essential role in controlling these complications. Thus, evaluation of the glycemic control status is crucial in the management of DM. H...
متن کاملMeasurement of Hemoglobin A1c
Evaluation of glycemia is used for the diagnosis and management of patients with diabetes. Glucose and hemoglobin A1c (HbA1c) provide complementary information and both are used to assess an individual’s glycemic status. The concentration of glucose in the blood indicates the subject’s glycemia at the time of blood sampling. However, blood glucose concentrations are modified by numerous factors...
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A 52-year-old woman with a medical history of hepatitis B, hyperlipidemia, hypertension, anemia, and depression presented to the internal medicine clinic for a routine visit. Laboratory tests 3 months previously had revealed an impaired fasting glucose concentration of 5.9 mmol/L (106 mg/dL) [reference interval, 3.9 –5.6 mmol/L (70 –100 mg/dL)]. Therefore, a hemoglobin (Hb) A1c analysis was per...
متن کاملHemoglobin Himeji and inconsistent hemoglobin A1c values: a case report
BACKGROUND Hemoglobin A1c is used to evaluate the glycemic control in patients with diabetes and is a risk marker for chronic complications of diabetes. Hemoglobin variants are reported to falsely lower or increase hemoglobin A1c test results. We present a case report of a patient with diabetes with discrepancy between fasting plasma glucose and hemoglobin A1c due to the presence of hemoglobin ...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2003
ISSN: 0009-9147,1530-8561
DOI: 10.1373/49.8.1245